Speaking with MTV, Nintendo of America's Reggie Fils-Aime said "Our expectation is that most of the content will be, call it, DSi-enhanced vs. DSi-exclusive."
"Why? One hundred-million installed base of DS. Developers are going to want to leverage that installed base and yet they’ll want to provide extra content via the features of the DSi, like the camera. That’s my expectation as to how it will play out."
Asked whether the new Zelda will be enhanced for DSi, Reggie just teased saying "wouldn't that be nice."
You can read the full interview with Reggie at MTV.